• More than 350M people globally living with type 2 diabetes
• Diabetes is the leading cause of kidney failure, lower-limb amputations & blindness in adults
• Average annual medical expenditure > 2.3X higher for diabetics
• US$35Bn annual expenses for type 2 diabetes medical therapies
• Average type 2 patient is on more than 6 prescription medications
• Fewer than 50% of patients achieve HbA1c target
• Polypharmacy result in regular tolerability issues for more than 70% of patients
• Therapeutic inertia delays therapy progression in 50% of patients
• Only 40% of patients are compliant with medical therapy after 12 months